Simulation of caspases apoptotic signalling pathway in a tuple space-based bioinformatics infrastructure

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Maura Cárdenas-García, Pedro Pablo González Pérez, Sara Montagna
EMBnet.journal 18(B)

Motivation and Objectives
Understanding intracellular communication processes is essential, since they allow the cell to perform the totality of its functions. Among them each cell has a self-destruction system that starts and operates in a regulated manner. It is called apoptosis, and includes the decision to start self-destruction as well as the proper execution of the apoptotic program. Caspases, a family of cysteine proteases, are the central regulators of apoptosis. As such, it requires the coordinated activation and execution of multiple sub programmes.