Modeling intercellular communication as a survival strategy of cancer cells: An in-silico approach on a flexible bioinformatics framework

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Maura Cárdenas-García, Pedro Pablo González Pérez, Sara Montagna, Oscar Sánchez Cortés, Elena Hernández Caballero
Bioinformatics and Biology Insights 10, pages 518
March 2016

Intercellular communication is very important for cell development and allows a group of cells to survive as a population. Cancer cells have a similar behavior, presenting the same mechanisms characteristic of tissue formation. In this work, we model and simulate the formation of different communication channels that allow an interaction between two cells. This is a first step in order to simulate in the future processes that occur in healthy tissue when normal cells surround a cancer cell, and to interrupt the communication, thus preventing the spread of malignancy into these cells. The purpose is to propose key molecules, which can be targeted to allow us to break the communication between cancer cells and surrounding normal cells. The simulation is carried out using a flexible bioinformatics platform developed by us, which is itself based on the metaphor chemistry based model.