In this thesis starting from the syntactic limits present in the exchange of Electronic Patient Records (EHRs), we aim to create a framework that provides the exchange of semantic information. The framework created is called Semantic TuCSoN and it is an extension of TuCSoN (Tuple Centres Spread over the Network) with the additional feature of allowing to exchange semantic information and by reasoning about them. Semanitc TuCSoN is afterwards modelled on the eHealth context by defining the Agents and coordination policies aimed at the exchange of EHRs, by providing to it of the data persistence, required to work in a real environment. Finally we do some test, based on the scenarios of interest, in order to evaluate its subsequent use in this area.