The talk discusses the issue of finding suitable modelling approaches for capturing multicellular system dynamics. Computational models and tools envisioned by our group are presented. In particular the talk introduces  the Biochemical Tuple Spaces (BTS-SOC) coordination model adopted to simulate structured biochemical systems, (ii) MS-BioNET developed to efficiently simulate multi-compartment systems and (iii) ALCHEMIST developed for supporting chemical models of multi-compartment dynamic networks.