The impact of mobile technologies on healthcare is particularly evident in the case of self-management of chronic diseases, where they can decrease spending and improve the patient quality of life. In this talk we propose the adoption of agent-based modelling and simulation techniques as built-in tools to dynamically monitor patient health state and provide feedbacks for self-management. To demonstrate the feasibility of our proposal we focus on Type 1 Diabetes Mellitus as our case study, and provide some preliminary simulation results.