Lineage Commitment of Hematopoietic Stem Cells: An Agent-based Model


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Andrea Roli  /  Andrea Omicini, Sara Montagna

It is time for agent-based modelling (ABM) to go beyond the "me too" stage, and finally deliver up to its promises.
To this end, agent-based techniques should be tested against scenarios that have proven to be too complex for traditional approaches. In this paper, we take a complex problem in the biological domain  lineage commitment of Hematopoietic Stem Cells (HSC) , and introduce an articulated agent-based model accounting for both intra- and inter-cellular aspects.
An implementation of the model in MASON is presented, and the first simulation results are discussed.

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MAS&Bio'08

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11/09/2008

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