The impressive development of wearable computing and augmented/mixed reality technologies that has been occurring in recent years allows for devising ICT systems that can bring a disruptive innovation in how emergency medical operations take place. In this paper the authors describe first explorations in that direction, represented by a distributed collaborative system called SAFE (Smart Augmented Field for Emergency) for teams of rescuers and operators involved in a rescue mission. SAFE is based on the integration of wearable computing and augmented reality technologies with intelligent agents and multi-agent systems.