A Model for Drosophila Melanogaster Development from a Single Cell to Stripe Pattern Formation


Sara Montagna, Danilo Pianini, Mirko Viroli

Proceedings of the 27th Annual ACM Symposium on Applied Computing (SAC 2012) , pages 14061412
26-30 March 2012
ACM, Riva del Garda (Trento), Italy
Dongwan Shin, Chih-Cheng Hung, Jiman Hong (eds.)

The development of multicellular organisms, from the early forms of zygote, involves a range of phenomena that control cell growth and differentiation, making the overall process of morphogenesis highly complex. A well studied example of such a huge phenomenon is given by Drosophila Melanogaster morphogenesis that has been object of several models, whose main goal was to investigate the mechanisms involved in the spatial and temporal evolution of the patterning process. They have been identified in gene regulatory network, morphogen diffusion, synthesis and degradation.
In this paper we present a model of Drosophila development that considers also nuclear division and movements as basic morphogenetic mechanisms. The model is run on top of a prototype simulator which is based on a variation of an existing SSA (Stochastic Simulation Algorithm), tailored to the specific features of embryo development, including dynamicity of compartment network topology.

 @inproceedings{montagna-sac12,
booktitle = {Proceedings of the 27th Annual ACM Symposium on Applied Computing (SAC 2012) },
publisher = {ACM},
author = {Montagna, Sara and Pianini, Danilo and Viroli, Mirko},
title = {A Model for Drosophila Melanogaster Development from a Single Cell to Stripe Pattern Formation},
isbn = {978-1-4503-0857-1},
year = 2012,
status = {Published},
pages = {1406--1412},
venue = {SAC},
editor = {Shin, Dongwan  and Hung, Chih-Cheng and Hong, Jiman},
address = {Riva del Garda (Trento), Italy},
month = {26-30 March}

Events

  • 27th Annual ACM Symposium on Applied Computing (SAC 2012) — 26/03/2012–30/03/2012

Publication

— authors

Sara Montagna, Danilo Pianini, Mirko Viroli

— editors

Dongwan Shin, Chih-Cheng Hung, Jiman Hong

— status

published

— sort

paper in proceedings

Venue

— volume

Proceedings of the 27th Annual ACM Symposium on Applied Computing (SAC 2012)

— pages

14061412

— publication date

26-30 March 2012

Identifiers

— print ISBN

978-1-4503-0857-1

BibTeX

— BibTeX ID
montagna-sac12
— BibTeX category
inproceedings

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