A Multiscale Agent-based Model of Morphogenesis in Biological Systems


Sara Montagna, Andrea Omicini, Alessandro Ricci

WOA 2010 — Dagli oggetti agli agenti. Modelli e tecnologie per sistemi complessi: context-dependent, knowledge-intensive, nature-inspired e self-* , pages 23-29
CEUR Workshop Proceedings 621, 5-7 September 2010
Sun SITE Central Europe, RWTH Aachen University
Andrea Omicini, Mirko Viroli (eds.)

Studying the complex phenomenon of pattern formation created by the gene expression is a big challenge in the field of developmental biology. This spatial self-organisation autonomously emerges from the morphogenetic processes and the hierarchical organisation of biological systems seems to play a crucial role. Being able to reproduce the systems dynamics at different levels of such a hierarchy might be very useful. In this paper we propose the adoption of the agent-based model as an approach capable of capture multi-level dynamics. Each cell is modelled as an agent that absorbs and releases substances, divides, moves and autonomously regulates its gene expression.
As a case study we present an agent-based model  of Drosophila melanogaster  morphogenesis. We then propose a formalisation of the model which clearly describe its main components. We finally show simulation results demonstrating the capability of the model of reproducing the expression pattern of the embryo.

 @inproceedings{abmmorpho-woa2010,
Address = {Rimini, Italy},
Author = {Montagna, Sara and Omicini, Andrea and Ricci, Alessandro},
Booktitle = {WOA 2010 -- Dagli oggetti agli agenti. Modelli e tecnologie per sistemi complessi: context-dependent, knowledge-intensive, nature-inspired e self-*},
Editor = {Omicini, Andrea and Viroli, Mirko},
Issn = {1613-0073},
Month = {5-7~} # sep,
Pages = {23--29},
Pdf-Url = {http://CEUR-WS.org/Vol-621/paper04.pdf},
Publisher = {Sun SITE Central Europe, RWTH Aachen University},
ScopusId = {2-s2.0-84868676924},
Series = {CEUR Workshop Proceedings},
Title = {A Multiscale Agent-based Model of Morphogenesis in Biological Systems},
Volume = 621,
Year = 2010

Journals & Series

Events

  • 11º Workshop Nazionale “Dagli Oggetti agli Agenti” (WOA 2010) — 05/09/2010–07/09/2010

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Publication

— authors

Sara Montagna, Andrea Omicini, Alessandro Ricci

— editors

Andrea Omicini, Mirko Viroli

— status

published

— sort

paper in proceedings

Venue

— volume

WOA 2010 — Dagli oggetti agli agenti. Modelli e tecnologie per sistemi complessi: context-dependent, knowledge-intensive, nature-inspired e self-*

— series

CEUR Workshop Proceedings

— volume

621

— pages

23-29

— publication date

5-7 September 2010

URLs

original PDF

Identifiers

— IRIS

11585/93512

— Scopus

2-s2.0-84868676924

— print ISSN

1613-0073

BibTeX

— BibTeX ID
abmmorpho-woa2010
— BibTeX category
inproceedings

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