Agent-based Modelling in Multicellular Systems Biology

Sara Montagna, Andrea Omicini

Multi-Agent Based Simulations Applied to Biological and Environmental Systems, cap. 7, pp. 159-178
Advances in Computational Intelligence and Robotics (ACIR), febbraio 2017
IGI Global
Diana Francisca Adamatti (a cura di)

This chapter aims at discussing the content of multi-agent based simulation (MABS) applied to computational biology, i.e, to modelling and simulating biological systems by means of computational models, methodologies, and frameworks. In particular, the adoption of agent- based modelling (ABM) in the field of multicellular systems biology is explored, focussing on the challenging scenarios of developmental biology. After motivating why agent-based abstractions are critical in representing multicellular systems behaviour, MABS is discussed as the source of the most natural and appropriate mechanism for analysing the self-organising behaviour of systems of cells. As a case study, an application of MABS to the development of Drosophila Melanogaster is finally presented, which exploits the ALCHEMIST agent-based simulation platform.

Author = {Montagna, Sara and Omicini, Andrea},
Booktitle = {Multi-Agent Based Simulations Applied to Biological and Environmental Systems},
Doi = {10.4018/978-1-5225-1756-6.ch007},
Editor = {Adamatti, Diana Francisca},
Isbn = {978-1-5225-1756-6},
Isbn-10 = {1-5225-1756-1},
Isbn-Online = {978-1-5225-1757-3},
Issn = {2327-0411},
Issn-Online = {2327-042X},
Month = feb,
Pages = {159--178},
Publisher = {IGI Global},
ScopusId = {2-s2.0-85018569036},
Series = {Advances in Computational Intelligence and Robotics (ACIR)},
Title = {Agent-based Modelling in Multicellular Systems Biology},
Url = {},
Year = 2017

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