Agent-based Modelling in Multicellular Systems Biology

Last modified by Andrea Omicini on 2021/01/05 14:21

Sara Montagna, Andrea Omicini

This chapter aims at discussing the content of multi-agent based simulation (MABS) applied to computational biology, i.e, to modelling and simulating biological systems by means of computational models, methodologies, and frameworks. In particular, the adoption of agent- based modelling (ABM) in the field of multicellular systems biology is explored, focussing on the challenging scenarios of developmental biology. After motivating why agent-based abstractions are critical in representing multicellular systems behaviour, MABS is discussed as the source of the most natural and appropriate mechanism for analysing the self-organising behaviour of systems of cells. As a case study, an application of MABS to the development of Drosophila Melanogaster is finally presented, which exploits the ALCHEMIST agent-based simulation platform.

Data Analytics in Medicine: Concepts, Methodologies, Tools, and Applications, Ch. 20, pages 369-389, 2020, IGI Global
	author = {Montagna, Sara and Omicini, Andrea},
	booktitle = {Data Analytics in Medicine: Concepts, Methodologies, Tools, and Applications},
	chapter = 20,
	doi = {10.4018/978-1-7998-1204-3.ch020},
	irisid = {11585/786747},
	isbn = {9781799812043},
	isbn-10 = {1799812049},
	isbn-online = {9781799812050},
	note = {Reprint},
	pages = {369--389},
	publisher = {IGI Global},
	title = {Agent-based Modelling in Multicellular Systems Biology},
	url = {},
	year = 2020}



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